Hepatoprotective Activity Of Phyllanthus longiflorus Heyne Ex. Hook. F. Against Acetaminophen Induced Hepatotocxicity In Rats

The present study was conducted to evaluate the hepatoprotective activity of ethanolic extract of Phyllanthus longiflorus (EEPL) leaf against acetaminophen induced liver damage in Albino rats. The ethanolic extract of Phyllanthus longiflorus (EEPL) (200 and 400mg/kg) was administered orally to the animals with hepatotoxicity induced by acetaminophen (835mg/kg). Silymarin (3mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 40% polyethylene glycerol solution. The plant extract was effective in protecting the liver against the injury induced by acetaminophen in rats. This was evident from significant reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein, albumin and total bilirubin. Histopathological studies of the liver showed swelling and necrosis in hepatocytes in acetaminophen treated rats, treatment with different doses of EEPL have significantly reduced the necrosis and swelling of the hepatocytes. It was concluded from the result that the ethanolic extract of P.longiflorus possesses hepatoprotective activity against acetaminophen induced hepatotoxicity in rats